Mitochondrial Dysfunction Triggered by T-2 Toxin-Induced Thioredoxin Reductase 2 (TXNRD2) Depletion and Its Molecular Mechanism.
The T-2 toxin is a prevalent trichothecene mycotoxin that threatens food safety and animal health, yet its direct mitochondrial targets remain poorly defined. Using network toxicology and in vitro validation in porcine renal PK15 cells, thioredoxin reductase 2 (TXNRD2) was identified as the most significantly downregul...