Melatonin ameliorates manganese-induced neurological deficits in mice by inhibiting TXNIP signaling-mediated neuroinflammation and microglial pyroptosis: Role of SIRT6.
Manganese (Mn) overexposure induces neurocognitive deficits associated with hippocampal neuronal injury and neuroinflammation, but the cellular mechanisms underlying Mn-induced hippocampal damage remain incompletely understood. Microglial pyroptosis may amplify neuroinflammation and contribute to secondary neuronal inj...