Diabetic wounds are refractory due to persistent inflammation and impaired angiogenesis, with traditional treatments having limited therapeutic effects. As promising cell-free therapeutic agents, exosomes can regulate wound inflammation and accelerate angiogenesis, while their clinical application is restricted by rapi...
The results indicate that calcium overload, FTY720-mediated TRPM7 inhibition, and MnO2-induced redox imbalance can drive PANoptosis, offering a new concept for enhancing cancer immunotherapy.
Aiyang Tong, Yang Zhou, Yang Ding et al.· Materials Today Bio· 0 citations
By inciting mitochondrial damage, provoking ROS buildup, and decoupling the protective autophagy-Nrf2/xCT axis, PNPT1 promotes osteoclastogenesis, thereby introducing a promising immunopharmacological target for restraining pathological bone resorption.
Cheng-Yan Liu, Xinlin Nie, Fangze Xing et al.· International Immunopharmaco...· 0 citations
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