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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Changyuan Guo

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Review Open access Sep 2026

The Neuro-stromal-immune Axis in Triple-negative Breast Cancer: Sensory Nerves Drive Immune Exclusion and Therapeutic Resistance

Triple-negative breast cancer (TNBC) exhibits substantial primary resistance to immune checkpoint blockade (ICB), a challenge driven largely by a desmoplastic and immunosuppressive tumor microenvironment (TME). Emerging multi-omics and spatial profiling technologies have unveiled the peripheral nervous system— specific...

Chang-Yuan Guo · 0 citations
Open access Sep 2026

ctDNA Release Heterogeneity in Luminal Breast Cancer Revealed by Single-Cell Multi-Omics Spatial Analysis

Backgroud Breast cancer is a leading cause of cancer-related mortality, and HR+/HER2− is the predominant subtype. Molecular pathology, including PIK3CA and ESR1 mutation, informs prognosis and treatment selection. Circulating tumor DNA (ctDNA) offers a non-invasive approach for cancer monitoring, but its clinical utili...

Heng-Yi Xu, Peng-Ming Pu, Bin-Liang Liu et al. · 0 citations

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