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Open access Aug 2026

AI-enhanced virtual screening identifies a potent small-molecule modulator of ClC-3 for cervical cancer drug discovery

ClC-3 chloride channels play essential roles in cervical cancer progression by regulating lysosomal acidification, cell volume homeostasis, and chemoresistance. However, no highly selective small-molecule modulators of ClC-3 have been reported to date. Motivated by the urgent clinical need to reverse ClC-3-mediated che...

Chao Liu, Chongxing Ji · 0 citations

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