Chaoqi He

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

ABSTRACT Lysosome‐targeting chimeras (LYTACs) have emerged as a strategy for eliminating secreted, extracellular, and plasma‐membrane proteins by redirecting them to the endolysosomal system. By coupling target recognition to receptor‐mediated uptake, LYTACs exploit endogenous trafficking pathways to access disease‐ass...

Nitrogen-doped carbon nanodots-based "off-on" fluorescent sensor for the detection of breast cancer-derived exosomes and early diagnosis.

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

ABSTRACT Targeted degradation of membrane proteins via the lysosomal pathway holds great therapeutic promise, yet existing platforms rely on bulky ligands such as glycopolymers, antibodies, or protein nanocages, which complicate synthesis and limit tissue penetration. Here, we repurpose L‑type amino acid transporter 1...

Dual-mode fluorescence and UV-vis aptasensor for hepatocellular carcinoma detection using magnetic separation

A dual-mode aptasensor based on magnetic separation with a sequential signal conversion mechanism is developed for sensitive and specific detection of HepG2 cells, exhibiting high specificity for HepG2 over other tumor cells.