Open access
Sep 2026
A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence
It is shown that elevated protein lactylation in EC correlates with heightened tumor stemness and unfavorable prognosis, and a metabolic–epigenetic mechanism linking lactate metabolism to m6A‐mediated stemness regulation is uncovered, establishing IGF2BP3‐K280 lactylation as both a therapeutic vulnerability and a preci...
Peng Jiang, Yun-Feng Zheng, Chen-Fan Tian et al.
· Advancement of science · 0 citations