Human cerebral organoids (COs) are well-recognized in vitro models for recapitulating human fetal brain development. However, spontaneous unguided differentiation of COs leads to severe regional heterogeneity, limiting standardized research and high-throughput drug screening. In this study, we generated optimized human...
Xiu-Ping Zhang, Ling-Liang Zhang, Xi-Yuan Wang et al.· Cells· 0 citations
BACKGROUND: Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombotic disease in patients. However, Metrnl...
Zhu-wei Miao, Can Chen, Pin Wang et al.· Circulation· 1 citation
Although organoid technology holds promise for advancing precision medicine, further optimization, validation, and integration with clinical studies are required before broader clinical applications can be realized.