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Author

Chao-Yu Miao

3 papers indexed here

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Open access Oct 2026

Enhanced Synaptic-Related Transcriptional Programs in Human Forebrain Organoids for Modeling Synaptopathy-Associated Neurodevelopmental Disorders

Human cerebral organoids (COs) are well-recognized in vitro models for recapitulating human fetal brain development. However, spontaneous unguided differentiation of COs leads to severe regional heterogeneity, limiting standardized research and high-throughput drug screening. In this study, we generated optimized human...

Xiu-Ping Zhang, Ling-Liang Zhang, Xi-Yuan Wang et al. · 0 citations
Open access Aug 2026

Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation

BACKGROUND: Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombotic disease in patients. However, Metrnl...

Zhu-wei Miao, Can Chen, Pin Wang et al. · 1 citation

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