Sep 2026
KIFC1 engages RUNX2/TGF-β signaling to promote lung cancer bone metastasis via disrupting bone homeostasis.
Jin-Yan Feng, Qing Zhao, Jin-Wu Wang et al.
· Oncogene · 0 citations
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Clinical trial
Open access
Aug 2026
T cell receptor repertoire dynamics and newly identified functional regulators of autologous tumor-infiltrating lymphocyte therapy in advanced solid tumors
The efficacy of TIL therapy in diverse solid tumors among Asian patients is demonstrated, dynamic TCR clonal remodeling in responders is revealed, and ASS1 and CEP20 knockout as strategies to potentiate antitumor activity are identified.
Fen-Ge Li, Ji-Long Yang, Gregory A. Lizee et al.
· Journal of Translational Med... · 0 citations
Review
Open access
Aug 2026
cGAS–STING pathway activation drives the cold-to-hot tumor transition and sensitizes immunotherapy
A detailed understanding of the cGAS-STING axis has substantial value in providing theoretical guidance and supporting clinical translation in the development of next-generation combination immunotherapies, as well as broadening the patient population benefiting from clinical interventions.
Xin-Ru Zhao, Shuai Meng, Hanzeng Cheng et al.
· Cancer Biology and Medicine · 0 citations