Author

Charles G. Danko

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Open access Aug 2026

Accurate de novo transcription unit annotation from run-on and sequencing data

A convolutional neural network was developed, called convolutional discovery of gene anatomy using PRO-seq (CGAP), trained to identify different anatomical features of a transcription unit, which were then stitched together into transcript annotations using a hidden Markov model (HMM).

Paul R. Munn, Jay Chia, Charles G. Danko · PLoS Computational Biology · 0 citations

Feb 2025

Accurate de novo transcription unit annotation from run-on and sequencing data

This work developed a convolutional neural network, called convolutional discovery of gene anatomy using PRO-seq (CGAP), trained to identify different anatomical features of a transcription unit, which were then stitched together into transcript annotations using a hidden Markov model (HMM).

Paul R. Munn, Jay Chia, Charles G. Danko · bioRxiv · 0 citations