Cis-element acquisition converts pervasive transcripts into translated mRNAs
The mammalian genome is pervasively transcribed into thousands of unstable non-coding RNAs, including promoter-upstream transcripts (PROMPTs) and enhancer RNAs (eRNAs). These pervasive transcripts are degraded by the nuclear exosome within minutes of synthesis and are never translated. Coding and non-coding transcripts...