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Charles J. David

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Open access Sep 2026

Cis-element acquisition converts pervasive transcripts into translated mRNAs

The mammalian genome is pervasively transcribed into thousands of unstable non-coding RNAs, including promoter-upstream transcripts (PROMPTs) and enhancer RNAs (eRNAs). These pervasive transcripts are degraded by the nuclear exosome within minutes of synthesis and are never translated. Coding and non-coding transcripts...

Rong-Jiang Zhang, Charles J. David · 0 citations

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