Charlotte A. Peterson

RNA splicing isoform alterations in muscle mitochondrial membranes of peripheral artery disease patients

Stress-induced metabolic reprogramming is thought to be paralleled by a reorganization of splicing programs, favoring alternative over canonical mRNA isoforms. In peripheral artery disease (PAD), lower extremity muscles are exposed to hypoxia and episodes of ischemia-reperfusion. These conditions may induce cellu...