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Charlotte E. J. Verkuijlen

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Open access Jul 2026

Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation

A capsid-targeting biological composed of a single-domain Llama VHH that binds CA, fused to human IgG1 Fc to activate TRIM21-mediated degradation results in inhibition of viral replication through TRIM21-mediated proteasome degradation of the HIV-1 capsid, establishing capsid-directed biologicals as therapeutic strateg...

Floor M. Stel, Charlotte E. J. Verkuijlen, Esther M. Zijlstra-Willems et al. · 1 citation

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