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Chase M. Webb

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Open access Sep 2026

G protein diffusion states reveal receptor binding dynamics at single-molecule scale.

G protein-coupled receptors (GPCRs) signal through heterotrimeric G proteins, yet the kinetics of receptor-G protein interactions in cells remain poorly understood. Using single-molecule imaging, we tracked individual Gαi1 proteins diffusing in the plasma membrane, expecting that receptor binding should slow these rapi...

Signe Mathiasen, Jozsef Meszaros, Chase M. Webb et al. · 0 citations

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