Author

Chen Chen

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Sep 2026

Discovery of a Novel HDAC1 Inhibitor to Potentiate Ferroptosis with Arachidonic Acid in ESCC

Ferroptosis represents a promising therapeutic strategy for esophageal squamous cell carcinoma (ESCC), but its efficacy is often limited by intrinsic metabolic defenses. Herein, arachidonic acid (AA) acts as a potent sensitizer for class I histone deacetylase (HDAC) inhibitor-induced ferroptosis. Guided by the bindin...

Meng Liu, Shan Gao, Chen Chen et al. · Journal of Medicinal Chemist... · 0 citations

Aug 2026

Tuning HDAC Inhibition, Cell Uptake, and Antiproliferative Activity of Vorinostat-Derived Half-Sandwich Complexes with Phosphine Co-Ligands.

HDAC inhibitors are used as anticancer drugs, and the Zn2+-coordinating hydroxamic acid moiety in the drug vorinostat (SAHA) plays a key role in the mode of action. The introduction of metal centers in the structures of HDAC inhibitors (HDACis) allows for additional interactions between the inhibitor and the protein. T...

Chen Chen, Barbora Havlinova, M. Vošahlíková et al. · Inorganic Chemistry · 0 citations