Author

Chen-Chen Li

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Aug 2026

Design, synthesis, and multitarget anti-Xanthomonas oryzae pv. oryzae mechanism of indole-3-substituted aryl urea derivatives.

BACKGROUND Bacterial leaf blight (BLB), caused by Xanthomonas oryzae pv. oryzae (Xoo), severely threatens rice production and global food security. Current commercial bactericides such as thiadiazole copper (TC) and bismerthiazol (BT) are losing efficacy due to widespread Xoo resistance, while research on structural mo...

Mengzhi Yang, Anbang Bai, Chen-Chen Li et al. · Pest Management Science · 0 citations

Jul 2026

Design, Synthesis, and Mechanistic Investigation of Novel 1,3,4-Thiadiazole Derivatives Bearing a Morpholine Moiety Against Xanthomonas oryzae pv Oryzae.

Mechanical studies revealed H6 inhibits biofilm and extracellular polysaccharide formation, disrupts membrane integrity, induces ROS accumulation, and promotes lipid peroxidation, underscoring H6 as a promising bactericidal agent, demonstrating considerable potential in sustainable management of plant bacterial disease...

Mengzhi Yang, Cheng-Peng Li, Yue Zhou et al. · Journal of Agricultural and... · 0 citations

Aug 2026

Novel Piperlongumine derivatives exert multimodal antitumor effects in prostate cancer via MAPK pathway activation, poly-mechanistic apoptosis induction, and DNMT3A-mediated DNA methylation reduction.

In vivo validation in PC-3 xenograft mice confirmed that 11 M exerted robust tumor growth suppression with low systemic toxicity, accompanied by DNMT3A downregulation and MAPK pathway activation, substantiating its multi-target therapeutic mechanism.

Yu Zhang, Xue Yang, Xuemei Qiu et al. · Bioorganic chemistry (Print) · 0 citations