Chen Deng

Integrative Genomic Analysis Reveals Insulin Resistance as a Key Mediator in the Causal Link between Metabolic Dysfunction–associated Steatohepatitis and Hypertension

Introduction: While metabolic dysfunction–associated steatohepatitis (MASH) is frequently associated with arterial hypertension, We used a multitiered Mendelian randomization (MR) framework to independently evaluate the causal link between MASH liability and hypertensive phenotypes. Methods: We performed a two-sample,...