Author

Chen Guo

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Aug 2026

FRET-based hypoxia-responsive self-quenching BODIPY nanoparticles enhance lung cancer efficacy while avoiding skin toxicity.

Photodynamic therapy is a promising antitumor modality with significant potential for clinical translation. Given phototoxicity, the development of photosensitizers that exhibit high tumor selectivity continues to be a critical research priority. To suppress the activity of photosensitizers in non-target tissues, a pho...

Chen Guo, Shan-Shan Chen, Jia Li et al. · Bioorganic chemistry (Print) · 0 citations

Sep 2026

Glutathione-Responsive Nano-Prodrug Mediates Synergistic Photothermal Chemotherapy for Tumor Inhibition

Photothermal therapy (PTT) offers the advantages of noninvasiveness and high selectivity, while chemotherapy shows potent antitumor activity. However, their standalone applications are limited by insufficient photothermal ablation efficacy and chemotherapeutic resistance, respectively. To address these challenges, we...

Yu Jiang, Chen Guo, Zhen-Kun Sun et al. · Molecular Pharmaceutics · 0 citations

Jul 2026

Dual-targeted pH-responsive nanoliposome (M5/NMN/DEAP/iRGD-Lip): Immunostimulatory-photodynamic synergy for breast cancer therapy.

This work synthesized iRGD-functionalized DSPE-PEG2000-iRGD and pH-sensitive HA-g-DEAP polymers, and fabricated multifunctional M5/NMN/DEAP/iRGD-Lip liposomes via the thin-film dispersion method, which possess pH responsiveness and enhanced tumor-targeting ability.

Junwei Zhuang, Chen Guo, Xingming Ye et al. · Colloids and Surfaces B: Bio... · 0 citations