Author

Chen-Hao Zhao

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Open access Aug 2026

Single-cell and spatial transcriptomics characterisation of RSPO2+ nucleus pulposus cells reveals a WNT/FN1–CD44 degenerative axis and therapeutic targets in IVDD

This study identifies an RSPO2-associated NP state and a candidate WNT/FN1–CD44 programme linked to IVDD, and provides a testable basis for future WNT-directed intervention studies while recognising the limits of acute rat models and cross-species data.

Qiu-Wei Li, Guoyan Liang, Kai-Da Bo et al. · Journal of Orthopaedic Trans... · 1 citation

Open access Jul 2026

MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc.

BACKGROUND Intervertebral disc (IVD) degeneration (IDD) is a leading cause of low back pain, with limited treatment options. The degenerative disc's harsh microenvironment promotes nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) death and hinders self repair. Mesencephalic astrocyte-derived neurotrophic facto...

Chen-Hao Zhao, Liang Kang, Jiaqi Wang et al. · Cell Biology and Toxicology · 0 citations