Review
Open access
Sep 2026
CCNE1: A Cell Cycle Regulator That Influences Tumor Progression
ABSTRACT Cyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric...
Liang Yan, Si-Yi Liu, Yan-Ling Li et al.
· Cancer Medicine · 0 citations