A gut microbiota–metabolite–host gene score for subtyping and predicting the treatment response in rheumatoid arthritis: integrative analysis with in silico knockout validation
The pathogenesis of rheumatoid arthritis (RA) involves a complex interplay between immune dysregulation and metabolic disturbance, with the gut microbiota and its metabolites playing pivotal roles. However, integrated biomarkers based on the “gut microbiota–metabolite–host gene” regulatory axis that can quantify its im...