Chen Wang

Affinity and costimulatory architecture-associated toxicity in mesothelin-targeted TCR-mimetic CAR-T cells

TCR-mimetic CAR-T combines antibody-based targeting with physiological TCR signaling, yet suboptimal co-stimulation and safety risks remain key barriers for solid tumor therapy. The prevailing assumption that stronger co-stimulation yields superior efficacy has not been systematically tested in TCR-mimetic CAR-T ar...

[Development of a rapid chimeric antigen receptor (CAR)-T production process and assessment of critical quality attributes].

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.

This work integrated single-cell profiling and spatial transcriptomics of glioma-associated microglia in the GL261 model to identify distinct microglial states that aligned with tumor architecture and highlighted microglial state transitions as a stage-specific layer of immune regulation in glioma that shapes T cell fa...