TP53 mutation may not only compromise its multifaceted tumor-suppressive functions but also confer oncogenic properties. Here, we demonstrate that DNA-binding domain mutations of TP53 unexpectedly confer a transcriptional regulatory function, directly driving RNA-splicing factor RBM28 overexpression. Overexpressed RBM2...
Tao Xiang, Zi-Yi He, Xiao Hu et al.· Nature Communications· 0 citations
Interpreting genetic risk variants within their relevant cellular contexts remains a central challenge in esophageal squamous cell carcinoma (ESCC), a malignancy with a substantial inherited component. We integrate single-cell RNA sequencing with genotype data to generate a cell-type-resolved expression quantitative tr...
Lina Song, Miao-Xin Pan, Yue-Ping Li et al.· Cell Reports· 1 citation
This study provides mechanistic insight into how m6A couples with an exonuclease in R-loop clearance and genome maintenance and uncovers a druggable epitranscriptional machinery that constrains the innate immune response and enables SCC immune evasion.
Jieyou Zhang, Kaiwen Bao, Yayan Hou et al.· Molecules and Cells· 0 citations
An HDGF/ENO1/H4K12la/iCAF axis that links tumor metabolic reprogramming, stromal inflammatory activation, and immunosuppression in ESCC is revealed, identifying this axis as a promising therapeutic target for overcoming immunotherapy resistance.
Zhengqing Song, Cai-Nan Li, Pujie Wu et al.· Cancer Letters· 0 citations
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