Pulmonary fibrosis is characterized by the persistent activation of fibroblasts into myofibroblasts, a process largely driven by TGF-β/SMAD signaling. Acetylation has emerged as a fundamental regulatory mechanism in cellular homeostasis and tissue fibrosis, yet whether and how the acetylation of core SMAD transcription...
The TGF-β1/TWIST2/TPI1 signaling axis is defined as an important regulator of pathogenic fibroblast behavior and pro-fibrotic responses through transcriptional control of TPI1, highlighting its potential as a therapeutic target for IPF.
Jiawei Chen, Yu Li, Kai Fu et al.· Cellular Signalling· 0 citations
Simple Summary From 1990 to 2023, China’s mesothelioma burden rose sharply, with cases up 189% and deaths up 142%, mainly affecting older males. While age-standardized death and disability rates stabilized or fell, population growth and aging drove the overall increase, and deaths are projected to keep rising through 2...
Kang Hu, Qichen Ye, Rong-Rong Zhao et al.· Cancers· 1 citation
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