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Oct 2026

Orchestrating polyketide synthase-derived aldehyde metabolism for Streptomyces biomanufacturing.

Advances in metabolic engineering have enabled the integration of diverse non-native reactions into microbial hosts, providing sustainable alternatives to petrochemical manufacturing. We previously developed a modular polyketide synthase (PKS)-based platform in Streptomyces albus for producing 17 diols, amino alcohols,...

Q. Dan, Xi-Na Wang, Yan Chiu et al. · 0 citations
Aug 2026

Unlocking Microbial Access to Amino-substituted 4-Hydroxycoumarin Derivatives via Enzymatic Promiscuity and Metabolic Engineering.

Coumarins and their derivatives possess diverse bioactivities and broad applications in pharmaceuticals, food additives, and materials science. For example, amino-functionalized coumarin derivatives hold significant promise for the development of novel functional materials and drug discovery. However, the microbial bio...

Caiyi Zhao, Jing-Qi Hou, Daphne Huang et al. · 0 citations

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