Author

Chen-Yu Wei

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Review Open access Sep 2026

Research advances on CD47 in digestive system cancers: from molecular mechanisms to clinical translation

CD47 is a major innate immune checkpoint molecule that interacts with signal regulatory protein α (SIRPα) to deliver a “don’t eat me” signal and restrain macrophage-mediated phagocytosis. Accumulating evidence indicates that dysregulated CD47 expression is associated with immune escape, treatment resistance, and advers...

Hao-Lin Sun, Chen-Yu Wei, Jiang-Lan Long et al. · Molecular Medicine · 0 citations

Review Aug 2026

Metabolic crosstalk between extracellular matrix, cancer-associated fibroblasts and tumor cells: drivers of tumor progression and therapeutic resistance.

This review clarifies the metabolic crosstalk mechanisms between ECM, CAFs and tumor cells, providing a theoretical basis for developing combinatorial therapeutic designs integrating metabolism-targeted agents, stroma-directed therapies and immunotherapy to amplify anti-tumor efficacy.

Chen-Yu Wei, Hao-Lin Sun, Jiang-Lan Long et al. · International Immunopharmaco... · 0 citations