Current genomic foundation models (GFMs) largely inherit the language-modeling paradigm over contiguous token sequences, treating DNA as ordinary text. The genome, however, is a coordinate-based system of sparse signals: the entities that matter, such as individual variants, regulatory elements, and distal gene interac...
Xu Yang, Chen-Chen Qin, Fang Wang et al.· bioRxiv· 0 citations
T cells play a crucial role in reducing disease severity during SARS-CoV-2 infection and in shaping long-term immune memory. However, the precise molecular immune responses, particularly involving T-cell receptor (TCR) repertoire changes after full vaccination, and the use of TCR analysis to evaluate vaccine efficacy,...
This work introduces TCRTSdesign, a framework that concurrently generates novel TCR sequences with specific binding capabilities to target pMHC molecules and predicts the full-atom structures of the TCR-pMHC complex, while optimizing their binding affinity.
Yang Xiao, Yu Zhao, Fandi Wu et al.· Proceedings of the 32nd ACM...· 0 citations
Designing functional T cell receptors (TCRs) for a given peptide presented by MHC (pMHC) is an emerging yet highly challenging problem in computational immunology. While recent approaches have achieved initial progress, they face two major limitations: (1) the lack of structural information from TCR–pMHC complexes in t...
Yang Xiao, Yu Zhao, Fandi Wu et al.· Proceedings of the 32nd ACM...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
