Oct 2026
SPP1+ TAMs drive colorectal tumorigenesis through an ARG2-orchestrated metabolic-immune crosstalk.
Rising incidence of colorectal cancer (CRC) and limited therapeutic options highlight the urgent need to define the drivers of its progression. The SPP1+ tumor-associated macrophage (TAM) subset identified by single-cell transcriptomics is a functionally dominant population that extends beyond the classical M1/M2 parad...
Lin-Hong Song, T. Yan, Shi-Yuan Lu et al.
· Cancer Letters · 0 citations