Evolutionary Adaptation and Targeted Metabolic Engineering Synergistically Improve Methanol‐Derived Single‐Cell Protein Production in Pichia pastoris
Methanol is a promising renewable C1 feedstock for sustainable single‐cell protein (SCP) production. However, its inherent cytotoxicity and metabolic trade‐offs between cell growth and protein synthesis remain significant bottlenecks. Here, we established an “evolutionary‐rational” dual‐driven paradigm to construct a h...