Author

Cheng-Guo Wu

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Open access Aug 2026

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

Cryo-EM analysis, enhanced-sampling molecular dynamics simulations, Markov state model construction, and transition-state analysis provide an atomic-level explanation for how the pathogenic E198K mutation allosterically promotes holoenzyme activation.

Michael S. O'Connor, Cheng-Guo Wu, Yi-Chong Lao et al. · bioRxiv · 0 citations