Author

Cheng-Jian Tan

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Open access Sep 2026

Optimization of extraction conditions for total flavonoids from Clerodendrum cyrtophyllum Turcz. and its antibacterial activity and mechanism against Staphylococcus aureus

Introduction Clerodendrum cyrtophyllum Turcz., a traditional Chinese medicinal plant, exhibits broad bioactivity. Nevertheless, the flavonoid constituents conferring anti-Staphylococcus aureus (S. aureus) activity and their mechanistic basis remain to be elucidated. Methods Total flavonoid extraction from Clerodendrum...

Yue Hu, Wen-Wen Luo, Cheng-Jian Tan et al. · Frontiers in Microbiology · 0 citations

Aug 2026

Integrated experimental and computational investigation of sophoridine derivatives reveals antitumor potential and Topo I-associated mechanisms.

Sophoridine is a quinolizidine-type natural alkaloid with favorable structural modifiability and diverse biological activities. However, the pharmacological potential of sophoridine derivatives originally optimized for insecticidal activity remains largely unexplored. Here, a bioactivity repurposing strategy was applie...

Ya-Kun Zhang, Jian‐Bo Tong, Hong-Yan Zhang et al. · European journal of medicina... · 0 citations