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Chengjie Zhou

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Open access Aug 2026

Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos

Spatial patterning of mRNA translation is a fundamental process in early embryogenesis. Existing RNA translation profiling methods lack subcellular spatial resolution at the single-molecule level, limiting our understanding of spatial RNA biology in embryogenesis. To address this, we profiled the spatial translatome of...

Jingyi Ren, Seth Furniss, Cheng-Jie Zhou et al. · 0 citations
Open access Sep 2026

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

Ch chromatin polyvalency model is established as a multi-layered, hierarchical repression mechanism that governs temporal control of gene expression during embryogenesis and disrupts temporal control of polyvalent gene activation.

Cheng-Jie Zhou, Meng Wang, Zhi-Yuan Chen et al. · 0 citations
Open access Aug 2026

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This work provides a mechanistic link between high-penetrance SETD1A variants and region-specific brain dysfunction, establishing a framework for connecting rare loss-of-function variation in chromatin regulators to multidimensional neuropsychiatric phenotypes.

Yiqiong Liu, Guoguang Xie, Shan Jiang et al. · 0 citations

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