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Cheng-Lu Lu

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Open access Sep 2026

Explainable machine learning for 2-year functional outcomes in older adults with aneurysmal subarachnoid hemorrhage in North China: external validation and health-system context

Older adults with aneurysmal subarachnoid hemorrhage (aSAH) have heterogeneous long-term outcomes, and differences in treatment pathways and hospital capacity may complicate early risk stratification. This multicenter cohort study included adults aged ≥60 years with aSAH in North China. Of 1,132 admissions...

Wen-Gao Zhang, Gang Li, Xi-Rui Wang et al. · 0 citations
Open access Aug 2026

A programmed cell death learning signature predicts immunotherapy response and identifies AP1S1 as a regulator of immune exclusion in breast cancer.

This study establishes the PCDsig developed is a potential prognostic and predictive biomarker for breast cancer and provides the first evidence of AP1S1 as a core immunomodulatory oncogene that mediates immune exclusion.

Gui-Xin Wang, Jun Cao, Parhat Kaysar et al. · 0 citations

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