To investigate the association and dose–response relationship between the cholesterol-modified prognostic nutritional index (CPNI) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM), and to evaluate its utility in identifying prevalent DR.
In this retrospective cross-sectional stu...
Shi-Meng Huang, Li Wang, Cong-Shu Zhang et al.· Frontiers in Nutrition· 0 citations
ABSTRACT Background Diabetic retinopathy (DR), a leading cause of blindness in diabetes, involves dysregulated neuroimmune crosstalk. While microglial activation and endothelial dysfunction are established in DR, the molecular mechanisms linking innate immunity to blood‐retinal barrier (BRB) breakdown remain elusive. M...
Diabetic retinopathy (DR) is a sight-threatening microvascular complication characterized by blood-retina barrier (BRB) disruption. While inflammation is central to early DR, the role of the non-canonical NF-κB pathway remains poorly understood.
We established a murine DR model and performed RNA-seq. Retin...
Hong-Xue Li, Qian Xu, Cheng-Ye Xu et al.· Journal of Translational Med...· 1 citation· ⚡1
Background The Leukocyte Glucose Index (LGI) reflects systemic inflammation and glycemic burden and has shown promising predictive value in cardiovascular and metabolic diseases. However, its association with prevalent diabetic retinopathy (DR) remains unclear. We investigated the association and dose–response relation...
Shi-Meng Huang, Li Wang, Cong-Shu Zhang et al.· Frontiers in Endocrinology· 0 citations
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