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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Cheng Zhan

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Review Sep 2026

Metabolic reprogramming underlying EGFR-TKI resistance in lung cancer.

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the clinical efficacy in non-small cell lung cancer (NSCLC) patients with EGFR mutations. However, acquired resistance to EGFR-TKIs remains an unavoidable therapeutic bottleneck. The metabolic reprogramming underlying th...

Xiao-Long Huang, Tao Cheng, Fengkai Xu et al. · 0 citations
Review Sep 2026

Antibody therapeutics: A new era for EGFR-mutant NSCLC treatment.

A major focus of this review is antibody-drug conjugates (ADCs) targeting novel surface antigens, including HER2, HER3, and TROP2, which have demonstrated remarkable clinical efficacy in EGFR TKI-resistant settings.

Xin-Ran Chen, Jia-Qi Liang, Jun-Kan Zhu et al. · 0 citations
Open access Jul 2026

ERK/GATAD2A/SAA1 axis drives osimertinib resistance via NF-κB and macrophage reprogramming in EGFR-mutated lung adenocarcinoma

Target neutralization of SAA1 synergized robustly with osimertinib to reverse immunosuppressive remodeling and induce profound tumor regression in multiple preclinical models, highlighting SAA1 neutralization as a tractable combinatorial strategy to enhance EGFR-TKI efficacy in LUAD.

Jun-Kan Zhu, Shencheng Ren, Tao Cheng et al. · 0 citations

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