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Author

Cheng Zhang

2 papers indexed here

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Open access Sep 2026

Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

Allosteric modulators offer opportunities for pathway-selective G protein–coupled receptor (GPCR) signaling, but the mechanisms enabling biased allosteric modulation remain poorly understood. We identify a helix 8–proximate allosteric site in the immune-metabolic receptor GPR84 and define how it achieves Gi-biased sign...

Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins et al. · 0 citations
Open access Jul 2026

Ligand-Specified Signaling Efficacy Defined by Unique Transitions in G Protein Conformations

This research established a 3-state model of Gαs conformational landscape and quantitatively investigated the conformational transitions and dynamics of Gαs proteins in response to different ligand-bound receptors, enabling a novel GPCR model that integrates quantitative G protein conformational dynamics at the atomic...

Xu-Dong Wang, Wen-Kai Sun, Nathan Hays et al. · 0 citations

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