Open access
Jul 2026
Nonpolysaccharide fraction of Lonicerae japonicae Flos attenuates cyclophosphamide-induced immunosuppression associated with modulation of the Keap1/Nrf2/HO-1/GPX4 signalling pathway
In vitro, LJFE dose-dependently activated the Keap1/Nrf2/HO-1 signalling axis and suppressed excessive NO release in LPS-challenged macrophages, and support the potential of LJFE for further development as an immune-enhancing functional food ingredient.
Mei Peng, Xiong Pan, Guanping Yao et al.
· Frontiers in Pharmacology · 0 citations