Open access
Aug 2026
Direct Substantia Nigra Deep Brain Stimulation in Parkinson's Disease: Efficacy, Safety, and the Frequency-Response Relationship.
Direct SN stimulation produced a clear frequency-dependent acute response in PD, with 130 Hz yielding the strongest motor and spatial gait benefits among the tested frequencies and effects of similar magnitude to standard STN stimulation.
Yu-Ye Liu, Chenguan Jiang, Bing-Xin Li et al.
· Brain Stimulation · 0 citations