Chengzhu Xu

Targeting ACOT1-SLC25A5 Axis attenuates LPS-induced acute liver injury by inhibiting ferroptosis and inflammatory responses.

It is demonstrated that ferroptosis was markedly activated in both lipopolysaccharide (LPS)-stimulated AML12 hepatocytes and LPS-induced acute liver injury mouse models, and ACOT1 exerts protective effects by modulating the PPARγ/NF-κB signaling axis and cooperating with SLC25A5 to regulate oxidative stress-driven ferr...