Open access
Jul 2026
Host OTUB2 and viral PLpro stabilize NSP8 to promote SARS-CoV-2 replication
It is demonstrated that the host deubiquitinase OTUB2 stabilizes the viral replication factor NSP8 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through a dual-track mechanism and identifies OTUB2 as a potential target for host-directed antiviral intervention.
Wenying Gao, Hongfei Wang, Jingguo Xin et al.
· Virologica Sinica · 0 citations