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Author

Chenqi Niu

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Oct 2026

A precursor-driven triterpenoid platform enables high-level biosynthesis of structurally distinct triterpenoids in Saccharomyces cerevisiae.

Sustainable microbial biomanufacturing of high-value triterpenoids in Saccharomyces cerevisiae is severely constrained by native sterol homeostasis, which rapidly channels the central intermediates 2,3-oxidosqualene (OSQ) and 2,3;22,23-dioxidosqualene (DOS) into essential ergosterol biosynthesis via lanosterol synthase...

Jing-Tao Zhou, Hai-Lang Ma, Chang-Wen Ye et al. · 0 citations
Aug 2026

Mechanistic Decoupling of the cis - and trans -Cleavage Activities of Cas12a via Phosphorothioate-Induced Kinetic Trapping

It is demonstrated that the availability of the RuvC catalytic channel is determined not by induced fit binding but by the chemical cleavability of the occupant, which provides a theoretical framework and additional insights for developing more precise gene-editing tools and designing Cas12a-based in vitro diagnostic p...

Chenqi Niu, Yiyi Mi, Wanxia Zhao et al. · 0 citations

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