Open access
Jul 2026
Exosome-mediated hepatocellular carcinoma progression by modulating macrophage metabolic reprogramming and macrophage M2 polarization via exosome-derived hsa_circ_0057320-miR-28-5p/E2F6 axis.
Exosomes derived from HOXD3-treated HCCs induced macrophage polarization toward the M2 phenotype via metabolic reprogramming, and exosomes derived from HOXD3-induced HCC cells promotes M2 macrophage polarization via metabolic reprogramming, thereby accelerating HCC malignancy.
Lu-Min Wang, Chenyang Qiao, Zhiqiang Wang et al.
· Journal of Translational Med... · 1 citation