Chew W. Cheng

Clonal hematopoiesis of indeterminate potential (CHIP), vascular somatic mutation, and cardiovascular disease: A narrative review

Somatic cell DNA mutations accumulate with age, and can give cells a survival advantage, resulting in their clonal expansion over time. We know that these mutations can lead to cancer, but the growing application of next-generation sequencing across multiple ‘healthy’ tissues has revealed their ubiquity and relevance t...