Author

Chi Lv

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Open access Aug 2026

Targeting a candidate stromal immune checkpoint: a cellular senescence signature identifies COMP⁺ cancer-associated fibroblasts associated with CD8⁺ T-cell exclusion via a predicted COMP-CD47 axis in colorectal cancer.

INTRODUCTION Resistance to immunotherapy in colorectal cancer (CRC) is closely linked to an immunosuppressive tumour microenvironment (TME), in which cancer-associated fibroblasts (CAFs) are key regulators. Cellular senescence and the senescence-associated secretory phenotype (SASP) are increasingly recognised as drive...

Yingying Chen, Ying Zhang, Chi Lv · Journal of Advanced Research · 0 citations

#explainable ai Review Open access Sep 2026

Artificial intelligence in non-small cell lung cancer: transforming diagnosis, treatment, and prognostic evaluation

Non-small cell lung cancer (NSCLC) is characterized by profound biological heterogeneity, frequently leading to late-stage diagnosis, recurrence, or metastasis. Conventional clinical pathways heavily depend on subjective visual interpretations, invasive tissue biopsies, and experience-based medical models that constrai...

Shuai-Yu Zheng, Chi Lv, Zhen Yao · Frontiers in Medicine · 0 citations