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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Chia-Wei Li

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Open access Aug 2026

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

ABSTRACT Despite advancements in immune checkpoint blockade (ICB) therapy, breast cancer shows limited response to anti‐PD1/PD‐L1 treatments, emphasizing the need for alternative ICB targets. Here, we reveal that endocrine therapeutics, specifically tamoxifen, create an immunosuppressive yet primed tumor microenvironme...

M. A. Aberin, Saurabh Singh, Soumya Chatterjee et al. · 0 citations
Open access Aug 2026

Smyca-FOXM1 ribonucleoprotein complex promotes homologous recombination and tumor immune evasion to define a therapeutic target of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options. Although PARP inhibitor (PARPi) offers great promise in treating TNBC with deficiency in homologous recombination (HR), most TNBC patients are HR-proficient. Furthermore, acquired resistance to PARPi rem...

Han-Hsiun Chen, Keng-Hao Chang, Sin-Rong Lee et al. · 0 citations

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