Chiaki Omura

An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss

Significance Current antiobesity therapies reduce body weight but often induce loss of lean mass and fail to achieve durable metabolic improvements after treatment ends. We show that an adipose-targeted RNA therapeutic targeting ZFP423, a transcriptional repressor of brown and beige fat identity, enhances thermogenesis...