Open access
Aug 2026
Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers
It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.
Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al.
· Nature Communications · 1 citation