Chiara Riviera

Better than hiding: high-grade glioma cells remodel the immune microenvironment to suppress cytotoxic immunity

Gliomas are aggressive brain tumors that progressively acquire a profound immune-evasive phenotype during malignant evolution. However, the mechanisms driving this transition from immune surveillance to immune tolerance are only partially understood. We used a PDGF-B-driven murine model in which sequential low- and...