Open access
Aug 2026
The natural coumarin 7-methoxy-8-isopentenyloxycoumarin alleviates LPS-induced inflammation by suppressing NF-κB and the MAPK/AP-1 pathways and accelerating COX-2 proteasomal degradation.
In vivo administration of 7MI dramatically improved survival rate and mitigated multi-organ damage in a murine model of fatal sepsis, highlighting its potential as a lead compound for LPS-associated inflammatory disorders.
Shiu-Wen Huang, Hsiu-Chen Chen, Antonio Lupia et al.
· European Journal of Pharmaco... · 0 citations