Review
Open access
Sep 2026
Recent advances in the precision synthesis of homogeneous N-linked glycoproteins: Synthetic strategies and discovery of latent functions.
Protein glycosylation crucially regulates the function and stability of mammalian membrane and secreted proteins. However, because biological glycan processing is inherently a non-template-driven process, natural glycoproteins exist as heterogeneous mixtures. This structural heterogeneity has historically hindered the...
K. Hirao, Hersa Milawati, Kentaro Yamada et al.
· Current Opinion in Chemical... · 0 citations